Product Details:
Alternate Name | 5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1 |
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Peptide Sequence | No |
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Appearance | Yellow solid |
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CAS # | 852391-15-2 |
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Molecular Formula | C₁₃H₁₂ClN₃O₂ |
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Molecular Weight | 277.71 |
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Purity | ≥96% by TLC and LC-MS |
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Solubility | DMSO |
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SMILES | CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl |
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InChi | InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19) |
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InChi Key | WIKGAEMMNQTUGL-UHFFFAOYSA-N |
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PubChem CID | 643953 |
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Handling | Protect from light and moisture |
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Storage Conditions | -20°C |
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Shipping Conditions | Gel Pack |
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USAGE | For Research Use Only! Not For Use in Humans. |
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biovision nec 1s
Descriptions:
A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.
Abstract
Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment that would effectively slow the growth of the aneurysm or prevent rupture. Necrosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently shown that a lack of RIP3 in mice prevented aneurysm formation.
The mean aortic diameter of Nec-1-treated mice appeared to be smaller (121.60 ± 10.40%) than the DMSO group, although the difference was not statistically significant (P = 0.1). Histologically, the aortic structure of Nec-1s-treated mice appeared normal, with continuous and organized elastin layers and rich SMCs expressing αActin.
In addition, Nect-1 treatment reduced macrophage infiltration and MMP9 accumulation and increased tropoelastin and lysyl oxidase aortic levels. Together, our data suggest that pharmacological inhibition of necrosis by Nec-1 stabilizes pre-existing aneurysms by reducing inflammation and promoting connective tissue repair.
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