biovision nec 1s

potent necroptosis inhibitor biovision nec 1s

Product Details:

Alternate Name5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1
Peptide SequenceNo
AppearanceYellow solid
CAS #852391-15-2
Molecular FormulaC₁₃H₁₂ClN₃O₂
Molecular Weight277.71
Purity≥96% by TLC and LC-MS
SolubilityDMSO
SMILESCN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
InChiInChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChi KeyWIKGAEMMNQTUGL-UHFFFAOYSA-N
PubChem CID643953
HandlingProtect from light and moisture
Storage Conditions-20°C
Shipping ConditionsGel Pack
USAGEFor Research Use Only! Not For Use in Humans.
biovision nec 1s

biovision nec 1s

 

Descriptions:

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.

Abstract
Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment that would effectively slow the growth of the aneurysm or prevent rupture. Necrosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently shown that a lack of RIP3 in mice prevented aneurysm formation.

The mean aortic diameter of Nec-1-treated mice appeared to be smaller (121.60 ± 10.40%) than the DMSO group, although the difference was not statistically significant (P = 0.1). Histologically, the aortic structure of Nec-1s-treated mice appeared normal, with continuous and organized elastin layers and rich SMCs expressing αActin.

In addition, Nect-1 treatment reduced macrophage infiltration and MMP9 accumulation and increased tropoelastin and lysyl oxidase aortic levels. Together, our data suggest that pharmacological inhibition of necrosis by Nec-1 stabilizes pre-existing aneurysms by reducing inflammation and promoting connective tissue repair.

 

Reservoir, 100ml sterile , Individually wrapped

P8100-1S 100/pack
EUR 106.7
Description: Reservoir 100ml sterile

FlowTubes with strainer cap, 12x75mm, individually wrapped, 500/cs

T9005-1S 500/pack
EUR 335.66
Description: FlowTubes with strainer cap 12x75mm

Microtubule-associated protein 1S Polyclonal Antibody

42570-100ul 100ul
EUR 333

Human Microtubule-associated protein 1S (MAP1S)

1-CSB-RP135494h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 31.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Microtubule-associated protein 1S(MAP1S),partial expressed in E.coli

(1S,2R)-2-(Boc-amino)cyclopentanecarboxylicacid

20-abx180085
  • EUR 356.00
  • EUR 1984.00
  • EUR 773.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

Tert-Butyl (1S,3R)-3-Hydroxycyclopentylcarbamate

20-abx185572
  • EUR 565.00
  • EUR 328.00
  • EUR 1344.00
  • 1 g
  • 250 mg
  • 5 g
  • Shipped within 1-2 weeks.

(1S,3S)-Methyl 3-aminocyclopentanecarboxylate hydrochloride

abx186027-1g 1 g
EUR 2764
  • Shipped within 1-2 weeks.

cis-(1S,2R)-2-Aminocyclopentanol hydrochloride

20-abx182399
  • EUR 495.00
  • EUR 3293.00
  • EUR 1163.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

Microtubule Associated Protein 1S (MAP1S) Antibody

20-abx113745
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

20-abx109998
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

abx145490-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

abx032611-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

abx032611-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

abx234975-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody

20-abx002312
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

(1S,2S)-(+)-N-p-Tosyl-1,2-diphenylethylenediamine

20-abx184505
  • EUR 272.00
  • EUR 481.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

(1S,2S)-2-Phenylcyclopropane-1-carboxylic acid

abx184838-1g 1 g
EUR 1469
  • Shipped within 1-2 weeks.

Microtubule Associated Protein 1S (MAP1S) Antibody (Biotin)

20-abx105663
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody (FITC)

20-abx107080
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody (HRP)

20-abx108501
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Microtubule Associated Protein 1S (MAP1S) Antibody Pair

abx117556-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1010
  • Shipped within 5-10 working days.

Microtubule-associated protein 1S Polyclonal Conjugated Antibody

C42570 100ul
EUR 397

(1S,6R)-8-Boc-3,8-diazabicyclo[4.2.0]octane

20-abx180087
  • EUR 2973.00
  • EUR 1107.00
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

20-abx181395
  • EUR 565.00
  • EUR 244.00
  • EUR 398.00
  • 10 g
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

(1S,2S)-N,N\'-Bismethyl-1,2-cyclohexane-diamine

20-abx185675
  • EUR 398.00
  • EUR 203.00
  • EUR 606.00
  • EUR 300.00
  • 10 g
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.

Human Complement Component 1s Subcomponent (C1S) ELISA Kit

20-abx150858
  • EUR 7112.00
  • EUR 3792.00
  • EUR 879.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

Human Complement Component 1s Subcomponent (C1S) ELISA Kit

abx251017-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Human Microtubule- associated protein 1S, MAP1S ELISA KIT

ELI-16380h 96 Tests
EUR 824

Mouse Microtubule- associated protein 1S, Map1s ELISA KIT

ELI-45907m 96 Tests
EUR 865

Cow Complement Component 1s Subcomponent (C1S) ELISA Kit

abx517405-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Rat Complement Component 1s Subcomponent (C1S) ELISA Kit

abx517407-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.